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Drug: Estradiol

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Position statement on the hormonal management of adult transgender and gender diverse individuals.
Authors: Cheung AS, Wynne K, Erasmus J, Murray S, Zajac JD Abstract INTRODUCTION: Rising demand for gender-affirming hormone therapy mandates a need for more formalised care of transgender and gender diverse (TGD) individuals in Australia. Estimates suggest that 0.1-2.0% of the population are TGD, yet medical education in transgender health is lacking. We aim to provide general practitioners, physicians and other medical professionals with specific Australian recommendations for the hormonal and related management of adult TGD individuals. MAIN RECOMMENDATIONS: Hormonal therapy is effective at aligning physical...
Source: Medical Journal of Australia - July 5, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

A retrospective study of estrogen in the pretreatment for medical management of early pregnancy loss and the inference from intrauterine adhesion
ConclusionsPretreatment with estrogen was not a sensible substitute for mifepristone in the medical management of early pregnancy loss. Mifepristone followed by carboprost methylate suppositories was likelihood of the ideal medical scheme in early pregnancy loss. IUA decreased the complete expulsion rate of medical management, it is cautious about medical management for early pregnancy loss with risk of IUA.Trial Registration Number: ChiCTR2100046503. Date of registration (retrospectively registered): May 18, 2021. Trial registration website:http://www.chictr.org.cn/.
Source: European Journal of Medical Research - July 25, 2022 Category: Research Source Type: research

Medical methods for first trimester abortion
CONCLUSIONS: Safe and effective medical abortion methods are available. Combined regimens (prostaglandin combined with mifepristone, letrozole, estradiol valerate, tamoxifen, or methotrexate) may be more effective than single agents (prostaglandin alone or mifepristone alone). In the combined regimen, the dose of mifepristone can probably be lowered to 200 mg without significantly decreasing effectiveness. Vaginal misoprostol is probably more effective than oral administration, and may have fewer side effects than sublingual or buccal. Some results are limited by the small numbers of participants on which they are based. A...
Source: Cochrane Database of Systematic Reviews - May 24, 2022 Category: General Medicine Authors: Jing Zhang Kunyan Zhou Dan Shan Xiaoyan Luo Source Type: research

Pediatricians Who Serve Trans Youth Face Increasing Harassment. Lifesaving Care Could Be on the Line
Dr. Gina Sequeira first saw the protesters on a bright clear morning last September. A co-director of Seattle Children’s Gender Clinic who provides gender-affirming care to young people, Sequeira had confronted ignorance about her medical specialty in the past. But nothing had prepared her to see people outside her office, waving signs and handing out flyers warning of the “dangers” of the work she does. “That was really, really hard for us as a clinic,” she says. “And I think it was really hard for the hospital’s patients and families who witnessed it.” Just a month later, p...
Source: TIME: Health - February 16, 2022 Category: Consumer Health News Authors: Madeleine Carlisle Tags: Uncategorized feature Health Care LGBTQ nationpod News Source Type: news

How reliable are “reputable sources” for medical information on the Internet? The case of hormonal therapy to treat prostate cancer
Conclusions: Few seemingly reputable Internet sources for medical information provide viewers with the detailed and up-to-date information that they may expect from such sites when searching for alternatives to standard treatment for androgen suppression. Strategies for keeping such websites up-to-date and reliable are discussed. Sites may improve their credibility and usefulness if they (1) present all evidence-based treatment options, (2) regularly update and time stamp their information, (3) acknowledge that their recommendations on treatments may become out-of-date quickly, (4) and direct viewers to information on rel...
Source: Urologic Oncology: Seminars and Original Investigations - November 9, 2012 Category: Urology & Nephrology Authors: Imhokhai Ogah, Richard J. Wassersug Tags: Clinical - Prostate Source Type: research

Low testosterone and the risk of dementia in elderly men: Impact of age and education.
CONCLUSIONS: Low levels of testosterone are associated with a risk for dementia in elderly men. The association between low bio-T and dementia may be more relevant to men 80 years or older and men with a high level of education. PMID: 24035146 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - September 17, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trial.
CONCLUSION: Metformin showed significant improvement in clinical outcomes but not in metabolic and endocrine outcomes in PCOS women; however, heterogeneity between studies was found to be moderate to high. PMID: 28058854 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Low testosterone and the risk of dementia in elderly men: Impact of age and education
Conclusions Low levels of testosterone are associated with a risk for dementia in elderly men. The association between low bio-T and dementia may be more relevant to men 80 years or older and men with a high level of education.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 10, 2014 Category: Geriatrics Source Type: research

Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men.
CONCLUSION: Low serum levels of SHBG are associated with higher prevalence of metabolic syndrome among male patients, but further studies are required to confirm this association. PMID: 24714992 [PubMed - in process]
Source: Sao Paulo Medical Journal - April 12, 2014 Category: Journals (General) Authors: Sá EQ, Sá FC, Oliveira KC, Feres F, Verreschi IT Tags: Sao Paulo Med J Source Type: research

Individual differences in risk taking and endogeneous levels of testosterone, estradiol, and cortisol: A systematic literature search and three independent meta-analyses
Publication date: Available online 3 May 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Jennifer Kurath, Rui Mata Hormonal levels have been hypothesized to serve as proximal biological mechanisms underlying individual differences in risk taking. We conducted a systematic literature search and independent meta-analyses to assess the link between endogenous testosterone, estradiol, and cortisol levels and risk-taking related constructs (i.e., risk-taking propensity, impulsivity, sensation seeking, novelty seeking). We found small correlations between risk-taking constructs and testosterone (r = 0.12...
Source: Neuroscience and Biobehavioral Reviews - May 3, 2018 Category: Neuroscience Source Type: research

De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon.
Abstract The sturgeon family includes many species that are lucrative for commercial caviar production, some of which face critical conservation problems. The purpose of this study was to identify genes involved in gonadal sex differentiation in sturgeons, contributing to our understanding of the biological cycle of this valuable species. A high-quality de novo Siberian sturgeon gonadal transcriptome was built for this study using gonadal samples from undifferentiated fish at 3, 5, and 6 months of age; recently sex-differentiated fish at 9 months of age; and immature males and females at 14-17 months of age. Undif...
Source: General and Comparative Endocrinology - August 3, 2018 Category: Endocrinology Authors: Vizziano-Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C Tags: Gen Comp Endocrinol Source Type: research

In search of neuroprotective therapies based on the mechanisms of estrogens.
Authors: DonCarlos LL, Azcoitia I, Garcia-Segura LM Abstract Although estradiol is a neuroprotective factor, estrogen therapy in older women increases the risk of adverse cognitive outcomes and poses additional peripheral risks, requiring careful use of estrogenic compounds as treatments for neurodegenerative conditions or neural injury. Potential alternatives to estrogen therapy to promote neuroprotection might include treatment with molecules that are able to interact with estrogen receptors, with alternative mechanisms of action, or with molecules that induce local estradiol synthesis in the brain, or a combinat...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Genetically predicted 17{beta}-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study
Conclusions Endogenous genetically predicted 17β-estradiol reduced low-grade systemic inflammatory markers (white blood cell count and granulocyte count), consistent with experimental and ecological evidence of 17β-estradiol promoting immune response. Replication in a larger sample is required.
Source: Journal of Epidemiology and Community Health - July 3, 2014 Category: Epidemiology Authors: Zhao, J., Jiang, C. Q., Lam, T. H., Liu, B., Cheng, K. K., Kavikondala, S., Zhang, W. S., Leung, G. M., Schooling, C. M. Tags: Smoking and tobacco, Epidemiologic studies, Cohort studies, Health education, Health promotion, Smoking Other topics Source Type: research

High levels of physical activity in female adolescents with anorexia nervosa: medical and psychopathological correlates
CONCLUSIONS: Results suggest that high levels of physical activity in acute AN associate with worst clinical conditions at admission, especially in terms of endocrinological and medical features.LEVEL OF EVIDENCE: Level III.PMID:33704692 | DOI:10.1007/s40519-021-01126-3
Source: Eating and weight disorders : EWD - March 11, 2021 Category: Eating Disorders & Weight Management Authors: Anna Riva Mariella Falbo Paolo Passoni Serena Polizzi Alessandro Cattoni Renata Nacinovich Source Type: research